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Cadmium which is one of these chemicals, has been shown to impair testicular functions by mimicking certain endogenous hormones thus disrupting normal endocrine processes (endocrine-disrupting compound (EDC [81] In our study, testosterone value in male offspring (PND90) was significantly decreased compared to the control
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Nanomedicine platforms offer precise tools for macrophage modulation, enabling the targeted delivery of polarization-inducing agents directly to the TME while sparing peripheral tissues (4750)accompanied by the robust activation of the NF-B and STAT1 pathways that drive the transcription of pro-inflammatory cytokines and immunostimulatory factors (51, 52)
These limitations need to be considered and challenges need to be addressed before wider implementation of TL as an established biomarker of aging in epidemiological research and clinical trials
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