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[63] He hypothesized that "EDTA could dissolve disease-causing plaques in the coronary systems of human beings." [64] In a series of 283 patients treated by Clarke et al

However, the study was small, lacked a placebo control and evaluated biomarkers rather than long-term clinical outcomes

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The label suggests 2 capsules daily (2,000 mcg total), but honestly, one capsule at 1,000 mcg felt strong enough for me