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Diabetes Obes Metab (2020) 22:313
Semaglutides pharmacological benefits are most effective when administered within a structured framework that supports gradual adaptation and metabolic consistency
Clinical studies show that while GLP-1 peptides like semaglutide and tirzepatide primarily reduce fat mass, some lean muscle is lost as well
Publication bias and poor recording of adverse events, which is common in clinical trials, may however explain such paucity of safety signals
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