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The initial 4-8 weeks are for building up a baseline level of pigmentation

In terms of its effects, it appears to impact drinking in ways (though not necessarily mechanisms) similar to naltrexone (FDA-approved) and topiramate (prescribed off label for alcohol use disorder), which have a greater effect in reducing intensity of drinking on drinking days relative to their effects on whether someone drinks at all (i.e., abstinent days) although all of them do increase abstinent days to some degree on average)

I am not trying to make the GLP-1 journey more complicated

Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome