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Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice