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Below is a curated list of key papers and reviews supporting low-dose GLP-1s for autoimmune and inflammatory conditions : Review of the preclinical and clinical evidence demonstrating anti-inflammatory actions of GLP-1 across organ systems, independent of weight loss Single dose of semaglutide has anti-inflammatory effects that protects the body from infection-induced inflammation, dependent on binding brain GLP-1 receptors GLP-1 receptors present on multiple different types of immune cells and has been shown to induce an anti-inflammatory profile Anti-inflammatory effects of GLP-1 dependent on reprogramming immune cells to anti-inflammatory profile and are independent of weight loss In trials in obese individuals with knee osteoarthritis, early improvements in osteoarthritis symptoms are observed in early weeks while patients are still on microdoses of semaglutide Low semaglutide exposure (blood levels) drive anti-inflammatory benefits HIV patients titrated up to 1 mg of semaglutide demonstrate reduction in pro-inflammatory factors, patients spent 25% of trial on microdoses Review of anti-inflammatory effects of GLP-1 in various preclinical and clinical trials, some using equivalent to low doses Note: The above statements have not been evaluated by the Food and Drug Administration

While this may in part reflect the different wound models used (incisional versus excisional), subsequent in vitro studies have shown that reduced angiogenic growth factors are responsible for an age-associated reduction in angiogenesis [166]

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