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Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides

Glutathiones reduced form (GSH): Carries an extra electron (hydrogen) Donates hydrogen (electron) to inflammation-causing free radicals to neutralize their effect Glutathione peroxidase enzyme Requires selenium Converts two hydrogen peroxides into two water molecules Glutathiones oxidized form (GSSG): State of glutathione after losing its electron Forms a disulfide bridge between two glutathione molecules Glutathione reductase enzyme Glutathione can be recycled back to its reduced form using NADPH (reducing agent, electron donor)

2020;48:D103141

The main mechanism of development of hyperthyroidism, according to Eckstein et al