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One of the most surprising findings, according to Gler, was how these drugs [activated] the emotion center and [engaged] the reward mechanisms in the brain. When the researchers gave mice a standard diet, which Gler described as the equivalent of salads for humans, the drugs had no effect

The satiety signaling goes beyond simply feeling full

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Because water-soluble vitamins like vitamin B12 are regulated by the kidneys, any excess that your body doesnt need will be excreted in your urine