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[281] [282] A third route starts with ethyl 3-oxobutanoate which through a double alkylation with methyl iodide followed by benzyl chloride can be converted into 2-methyl-3-phenyl-propanoic acid

f , Docking of flavan-3-on-4-ol ( 7 ) (yellow) into the active site of Pt GSTF8 and distances (in ) from the GSH (green) thiolate to C-2 and O-3 of 7 as well as distance of the C13 thiolate (purple) to GSH (green) 7

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