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This dual effect on both sides of the energy balance equation is why retatrutide produced the highest weight loss percentages of any single-agent trial

All of these contribute to GLP-1 fatigue, a feeling of exhaustion that doesnt always match your level of activity or sleep

AbbVies sales of Humira have fallen by two-thirds since a generic version hit the market in 2023, but the company still sold $4.5 billion worth of the drug last year.