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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility
9 Fanjiacun Road, Fengtai District, Beijing 100070, China More Information Corresponding authors: [email protected] (L.Y.)
MCAO + DSIP included animals subjected to MCAO and treated with DSIP
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