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Clinical trial data from the SURMOUNT-1 study showed that gastrointestinal adverse events were significantly more common during dose escalation periods (Jastreboff et al., 2022, NEJM)
For example, 1,000 mcg is 1 mL if the concentration is 1,000 mcg/mL
The initial inflammatory modulation begins within the first one to two weeks, but the functional changes, including improved flexibility, reduced global stiffness, and better circulation, accumulate over four to eight weeks as the compounds systemic effects build through repeated dosing
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