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In PsO, clinical studies evaluating GLP-1RAs such as liraglutide and semaglutide have reported significant improvements in PASI scores and histopathological skin features, effects that appear to be at least partially independent of weight loss ( Given the prominent role of IL-17driven inflammation in obese PsA patients, GLP-1RAs may also enhance the efficacy of biologic agents targeting these pathways
To date, no approved DSIP drug exists for a defined sleep indication, and large-scale controlled human trials are lacking
Structure compensates somewhat for reduced internal satiety signals
it addresses both the cellular trigger (oxidative stress in the mast cell) and the systemic clearance mechanism (hepatic detoxification)
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