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Therefore, it is not possible to define the real activation status of the IGF-1 receptor signaling through the mere dosage of circulating IGF-1 levels
From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)
Figure 20: Photograph of Professor Lelio Orci, credit: University of Geneva, Morriswood
CrossRef Overdiagnosis: epidemiologic concepts and estimation Jong-Myon Bae Epidemiology and Health.2015
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