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This consumes the cells principal methyl donor and removes nicotinamide from the salvage pathway that regenerates NAD+

4.2 Comparison and evaluation of different antioxidants When comparing the roles of vitamin C, vitamin E, and glutathione in the treatment of periodontitis, vitamin C mainly neutralizes water-soluble oxygen free radicals slike hydroxyl radicals and singlet oxygen, protecting the cellular environment and improving the oxidative status of periodontal tissues, resulting into the reduction of inflammation and damage