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Treatment with P@ZIF/M1-KTP significantly increases the ratio of CD4+ T cells and decreases MDSCs in tumor tissues, demonstrating the potential of combining nanoparticle drug delivery with cellular therapy to remodel the immunosuppressive TME (55)

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Although cell signaling studies are desirable for further evaluation of SR18 for obvious reasons, as an alternative, the agonistic potential of SR18 was preliminarily evaluated using computational structural biology techniques instead