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It is well-documented that metformin can cause nausea, bloating, and diarrhea, particularly when you first start the medication
doi:10.1001/jama.2024.3073
Functional studies on the enzyme have identified an N-terminal lipid-binding region, the / hydrolase fold domain including the catalytic triad, and the regulatory module containing all known phosphorylation sites important for regulation of enzyme activity
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