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As for using ALA topically, we have to say that its role and effects seem to be less direct than with LA

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A randomized, double-blinded, placebo-controlled trial published in the European Journal of Nutrition found that oral glutathione at 1,000 mg per day increased blood glutathione levels by 30 to 35% in erythrocytes, plasma, and lymphocytes after 6 months of consistent supplementation