semaglutide with cagrilintide and have each been shown to induce weight loss, but how these drugs work in combination in patients type 2 diabetes and overweight or obesity is unknown. Research findings Updates in Medicine | 🔬

437 In cisplatin-sensitive oral squamous cell carcinoma, the autophagy-associated protein LC3B-II was found to be enriched in EVs, potentially modulating drug sensitivity in neighboring cells via miRNA transfer, highlighting its promise as a noninvasive biomarker for cisplatin resistance

doi:10.2337/dc19-0883 Rosenstock J, Allison D, Birkenfeld AL, et al

These patients require immediate surgical drainage with the placement of a nephrostomy tube or ureteric stenting

this warrants ongoing monitoring No unexpected serious cardiovascular signals were identified during the limited Phase 2 follow-up period, though the trials were neither designed nor powered to assess cardiovascular outcomes, and longer-term data are not yet available At present, the overall safety profile appears broadly consistent with other GLP-1-based therapies, but definitive conclusions cannot be drawn until Phase 3 data and post-marketing surveillance are available