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Caffeine 11 increases cortisol levels, and this influence may be even more significant if other stressors are present

If hormones arent optimized, weight loss becomes much harder even with medication

Weight loss recommendations may be particularly important for patients at highest risk for weight gain and cardiovascular morbidity, such as young/premenopausal patients, postmenopausal patients with estrogen receptorpositive disease on endocrine therapy, and/or preexisting cardiovascular disease risk factors

Tirzepatide, a dual GIP/GLP1 receptor coagonist for the treatment of type 2 diabetes with unmatched effectiveness regarding glycaemic control and body weight reduction. Cardiovascular Diabetology