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B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease
However, those with an unbalanced diet or without access to fresh fruits and vegetables may not
GSH has long been implicated as a major antioxidant and redox regulator that functions to mitigate and alleviate this oxidative damage ( However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines
It is produced in the liver
