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The KELCH domain of the Keap1 homodimer binds to the DLG and ETGE motifs (ETGE acts as a hinge, and DLG acts as a latch) of the Neh2 domain of Nrf2 in the cytosol

In addition to redox imbalance, aging oocytes exhibit progressive genomic instability, deterioration of chromosome cohesion, and reduced efficiency of the spindle assembly checkpoint, all of which increase the risk of meiotic errors and aneuploidy

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Kurz: Glutathion ist ein lebensnotwendiges, an fast allen Stoffwechselvorgngen beteiligtes Eiwei, das die krpereigene Entgiftung reguliert und sehr stark antioxidativ wirkt