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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)
GPx3 is an extracellular enzyme which is abundantly present in the plasma [1, 8, 9]
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PTD-DBM is a synthetic peptide consisting of a protein transduction domain (for cell membrane penetration) fused to a Dishevelled binding motif (for targeting the CXXC5-Dishevelled interaction)
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