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SAMe has been shown to provide a benefit in a variety of liver disorders (modeled in experimental animals, in humans, and in dogs and cats), the molecular basis of SAMe's protective effects have been demonstrated in vitro using hepatocyte cell cultures

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PBMCs isolated from individuals with T2DM at baseline and three months post-supplementation with either L-GSH or empty liposomes were used for generating in vitro granulomas

This pattern may suggest an allergic response or other complication requiring evaluation