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The present inhibitor, CB-839, has been demonstrated to engender anticancer effects in a variety of cancers, including myeloproliferative neoplasms, CRC [138, 139]

Holotoxin delivery and cell viability (CellTiter-Glo assay) 6His-tagged proteases fused to the BoNT translocation domain via a thrombin-cleavable linker were expressed and purified as described above

Their early studies demonstrated that cyclic melanotan analogues produced potent, sustained melanogenesis in animal models at doses far lower than native -MSH

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