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Although prolonged appetite suppression with semaglutide might theoretically contribute to reduced nutrient intake, current evidence does not indicate a significant risk of specific micronutrient deficiencies, and the FDA has not identified micronutrient deficiency as a major safety concern in semaglutide approvals [28]
Several adipokines with effects on insulin action, energy metabolism or appetite control have been studied, but none has succeeded beyond initial clinical trials (ESM Appendix 3)
The drug alone produces less
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