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While current evidence does not establish a direct causal relationship between tirzepatide and gastrointestinal bleeding, tirzepatide's known gastrointestinal effectsincluding nausea, diarrhea, vomiting, and constipationmay indirectly contribute to conditions that cause rectal bleeding
Usually mild and self-resolving within hours
Body composition changes during weight reduction with tirzepatide in the SURMOUNT -1 study of adults with obesity or overweight
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