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[36] [39] In animals and plants, the first two steps of the saccharopine pathway are catalysed by the bifunctional enzyme, -aminoadipic semialdehyde synthase (AASS), which possess both lysine-ketoglutarate reductase (LKR) (E.C 1.5.1.8) and SDH activities, whereas in other organisms, such as bacteria and fungi, both of these enzymes are encoded by separate genes
AOD 9604 is mostly backed by animal study data, with limited human clinical evidence available in peer-reviewed literature
