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Several studies have shown that ketogenic diets significantly reduce hunger and food intake, likely due to the increased production of ketone bodies, stable glycemia and altered levels of appetite-regulating hormones

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When GLP-1 binds to GLP-1R on the surface of -cells, cAMP-dependent PKA is activated and subsequently activates the downstream signal PI3K, which inhibits apoptosis in islet -cells by blocking the expression of the pro-apoptotic protein Bax (Li et al., 2021) (Figure 4)