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Long-term safety data in humans does not exist for most injectable peptides
Its not all doom and gloom, however
As described above for PABA/NO, JS-K, and GSNO, the NHGs, in accordance with GT expression patterns, contribute to chemotherapy by producing locally high levels of NO which can rapidly react with O 2 - to generate the potent oxidant peroxynitrite that, in turn causes extensive cellular damage, including the nitration of protein tyrosine residues (Kirsch et al., 2001)
Additionally, the transcription factor YY2 has been identified as an endogenous repressor of CYP51A1 and can suppress cholesterol biosynthesis and tumor progression in hepatocellular carcinoma [77]
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