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During the acute phase of sepsis, glutathione synthesis is enhanced in the liver and other tissues, a process regulated by multiple factors, including a decreased reduced/oxidized glutathione ratio, reactive oxygen and nitrogen species, proinflammatory cytokines, heat shock proteins, and physical inactivity
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188 The PI3K/Akt signaling pathway is crucial for regulating key cellular processes in cancer, including cell survival, proliferation, angiogenesis, and metabolic reprogramming
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