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Endoplasmic reticulum stress If not quickly rectified, any of the above stresses activates the ER stress- unfolded protein response (UPR) which, in turn, exacerbates oxidative stress and elicits inflammation by activating stress response genes such as NF-kB (9, 122)

Following the initial 10-day period, researchers may consider switching to a maintenance dose of 2mg/weekly (8mg/month) as suggested by research involving long-term trials [17]

Gastrointestinal Medications: Proton Pump Inhibitors (PPIs) and H2 Antagonists : No significant interactions, but monitoring for altered drug absorption due to changes in gastric pH and motility is prudent

2009;(2):CD006659