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ACHIEVE-1 (NCT05971940) This trial evaluated orforglipron as monotherapy or add-on to metformin in adults with early type 2 diabetes
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Compared to Hexarelin (His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2, 887 Da): Ipamorelin does not activate the CD36 receptor expressed on cardiomyocytes, while hexarelin shows a CD36-mediated cardiotropic effect in rodent ischaemia models
Most people find the abdomen easiest for self-injection and report less discomfort compared to other sites
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