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Patients with pre-existing diabetic retinopathy should be aware that rapid improvement in blood glucose control may temporarily worsen retinopathy, particularly with semaglutide
170 In a randomized placebo-controlled trial involving 102 healthy individuals, 600 mg valerian extract an hour before bedtime did not cause morning sleepiness, poor concentration, or reduced reaction time after a single use or nightly use for two weeks, confirming the safety of valerian in healthy people
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