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If youre ready to explore this transition, TrimRxs intake quiz can connect you with a provider who manages semaglutide-to-tirzepatide switches regularly and can build a personalized titration plan based on your treatment history
TLDR: "Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity." Key findings: After stopping liraglutide, patients regained ~2.2 kg After stopping semaglutide/tirzepatide, patients regained ~9.7 kg Weight regain was proportional to initial weight loss Lifestyle changes alone DID NOT prevent regain Implication: GLP-1 receptor agonists are not a short-term solution
Thermogenic Effect: The digestion of protein requires more energy compared to fats or carbs, creating a thermogenic effect
doi: 10.2337/dc20-0498 70 LinXLiH
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