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In addition, in the EMPEROR-reduced trial, enrolling about 3700 patients affected by heart failure with reduced ejection fraction (HFrEF), empagliflozin significantly reduced the risk of heart failure hospitalization and decreased total hospitalization for HF regardless of the presence of diabetes or baseline levels of glycohemoglobin (HbA1c) (49, 50)
Waist circumference typically decreases with treatment, with the magnitude varying among individuals
Week 2: 2.1 pounds lost
Expected Amount of Weight Loss: In a STEP 1 trial, an average weight loss of 3.8% was reported after four weeks on the 2.4 mg semaglutide
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