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Vitamin B12 is a water-soluble vitamin essential to many key functions in the body

The studies showing incompatibility between niacinamide and vitamin C date back to the early 1960s (yes, that far)

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[7] Research has indicated a potential area of interest for DSIP in the study of withdrawal symptoms from opiate and alcohol addictions, which has been supported by the results of studies in animals conducted by Tissot and the fact, that DSIP possesses an agonistic activity on opiate receptors