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doi: 10.3389/fimmu.2026.1755316 Received 27 November 2025 Revised 11 July 2026 Accepted 22 July 2026 Published 03 August 2026 Volume 17 - 2026 Edited by Manuel Muro, Virgen de la Arrixaca University Hospital, Spain Reviewed by Paola Pontrelli, University of Bari Aldo Moro, Italy Benjamin Spector, University of Wisconsin-Madison, United States Updates Copyright 2026 Zhang, Zheng, Zheng, He, Chen, Luo, Wang and Cai

Perovic D, Kolenc D, Bilic V, Somun N, Drmic D, Elabjer E, et al

Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

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