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The GLP-3 peptide research and triple-agonist medications like retatrutide point to a future where multiple receptor targets are activated simultaneously

By integrating current evidence on phytochemicals, heavy metal toxicity, and emerging therapeutic strategies, this work aims to support the development of multi-targeted interventions for liver diseases

however, this represents early-phase evidence only, and the mechanistic effects observed in trials including increased energy expenditure and lipolysis via glucagon receptor agonism have not yet been fully characterised in long-term human studies