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Ice crystal formation during freezing physically damages the peptide structure in solution

17 These unique findings also highlighted a previously perceived, however poorly understood, interdependence between mucosal epithelium and overlying mucus layers, which collectively maintain the integrity of the mucosal barrier against luminal antigens (Figure 2)

A broader 2020 review by Sikiric and colleagues in Gut and Liver frames the compound's proposed GI activity within Robert's cytoprotection and organoprotection model the longstanding physiological framework describing how the gastric mucosa protects itself against injury

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