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As a beneficial property, inhibition of the inflammatory response did not impair wound healing and did not induce failed collagen synthesis (Mikus et al., 2001
Plateaus are a predictable biological event documented in the STEP and SURMOUNT trials, and they have specific, fixable causes receptor desensitization, sub-therapeutic dosing, calorie creep, lean-mass loss, or a genetic variant in GLP1R or GIPR that means population-average titration was never going to work for you
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