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Why CJC-1295/Ipamorelin Is Better Tolerated Compared to other GH secretagogues, this combination has a notably cleaner side effect profile: No cortisol spike: Unlike GHRP-6 and GHRP-2, Ipamorelin doesn't significantly increase cortisol levels Minimal prolactin increase: Important for avoiding prolactin-related side effects No desensitization: CJC-1295's mechanism doesn't appear to cause rapid receptor downregulation Physiologic GH release: Pulsatile pattern avoids the sustained high GH levels that cause more side effects with direct HGH Serious Side Effects (Rare) Significant edema: If water retention becomes severe (tight rings, significant facial puffiness), reduce dose and consult your physician Joint pain: GH can increase joint stiffness at higher doses
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Acknowledgments Authors want to thank Germaine Pugh and Cassia McClain for their invaluable help in preparing the manuscript, and Jessica Michelle Vasquez-Soltero for processing the gene profiling data
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