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Drug Discovery Today (2021) 26(8):19912002
Following a defined protocol not only protects your patients but also provides you with clinical and legal safeguards
Hyponatremia ( Na) Cause by GI loss (vomiting/diarrhea), Addisons disease, overhydration Effect: Lethargy, vomiting, seizures, brain swelling Hypernatremia ( Na) Cause by Dehydration, diabetes insipidus, heat stroke Effect: Intense thirst, tremors, walking drunk, seizures, coma (often from dehydration or salt poisoning)
The initial approved regimen was 5 g subcutaneous injection twice daily, given within 60 minutes before morning and evening meals, titratable to 10 g BID
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