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Clinical study characteristics All included studies were categorized based on key characteristics, including study duration, start year, geographical location and the number of clinical centers involved
Over-representation analysis of the DEGs was done by using ShinyGo 0.80 to show the top 20 pathways, ranked based on fold enrichment, and false discovery rate (FDR 0.05)
Duration of symptoms : If gastrointestinal symptoms persist beyond the initial titration period of Wegovy (typically up to 16 weeks), this may indicate poor tolerance rather than transient side effects
GLP-1 RA initiation was defined as the first-ever recorded prescription of any GLP-1 RA agent in the Luxmed database during the study period
