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However, insulin sensitivity and glucose tolerance were maintained, likely owing to an increased conversion of saturated fatty acids (known to cause insulin resistance) to monounsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1) [52]

doi: 10.1007/s13300-018-0428-y 133 McCartneyFGleesonJPBraydenDJ

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I tell patients early on that significant weight loss can temporarily unmask laxity in the lower face, neck, upper arms, and abdomen, and that hair shedding can occur for several months