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These hexapeptides showed appreciable GH-releasing potency but co-stimulated adrenocorticotropic hormone (ACTH), cortisol, and prolactin, a lack of selectivity that would become the central design problem for later compounds in the class
By prompting the pancreatic beta cells (-cells) to release more insulin when blood glucose levels are elevated, GLP-1s significantly lower the risk of hypoglycemia (low blood sugar) compared to traditional insulin or other types of type 2 diabetes medications
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Sales of Novo Nordisks (NVO) diabetes medication Ozempic, known for its weight-loss side effects, grew 26% to $16.7 billion in 2024
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