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For the enzymes affected by estradiol in one-carbon metabolism (yellow enzymes), as estradiol varies during the menstrual cycle, the multiplier of the V max of the enzyme is scaled between the male value and the female value in table 3 in [22]
Padua RA, Chiquet M, Zhang Q, Kappel C, Krief P, Setterblad N, Omidvar N, Leboeuf C, Janin A, Noguera ME, Konopleva M, Andreeff M , Pla M, Ades L, Fenaux P, Chomienne C
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As a result, many, including us at diaTribe, had expected Bydureon to gain approval this second time around, especially given the promising results indicated above and the apparent lack of notable safety concerns
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