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Leptin resistance where the hypothalamus no longer responds appropriately to adipokine signals is a hallmark of established obesity, as described in StatPearls (NCBI)
GLP-1 medications have been shown to reduce alcohol cravings in some studies
For patients who have been on semaglutide long-term and are considering discontinuation, the semaglutide withdrawal symptoms guide explains what to expect
Gastroenterology 132, 19251936
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