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While useful and still heavily relied upon, these traditional batch synthesis approaches can suffer from significant issues including complex impurity profiles due to incomplete reactions or double-addition, and significant challenges accessing difficult sequences [7], such as highly hydrophobic peptides that are prone to aggregation
Alogliptin In Vitro Assessment of Drug Interactions In vitro studies indicate that alogliptin is neither an inducer of CYP1A2, CYP2B6, CYP2C9, CYP2C19 and CYP3A4, nor an inhibitor of CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP2D6 at clinically relevant concentrations