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Bayesian data assimilation has been suggested as a method to integrate patient data and address uncertainty in individualized treatments, a strategy that may also be applicable to peptide-based therapeutics

Let water trickle down gently

Clearance of a drug by the liver is determined by hepatic blood flow (Q H ) and the intrinsic ability of the liver to extract the drug (extraction ratio, or ER H ) : Drugs with a high extraction ratio (approaching 1) have Cl H equal to the hepatic blood flow

Qamar et al ., 2024, "Setmelanotide: A melanocortin-4 receptor agonist for the treatment of severe obesity due to hypothalamic dysfunction"